make sure you have configured both the app.config and the programname.exe.config file.
for example:
<configuration>
<startup>
<supportedruntime version="v2.0.50727"/>
</startup>
</configuration>
"mixed mode assembly is built against version 'v2.0.50727' of the runtime and cannot be loaded in the 4.0 runtime - researched solutions not working" Code Answer
By
Jan Curn
on October 14 2022
Answers related to “mixed mode assembly is built against version 'v2.0.50727' of the runtime and cannot be loaded in the 4.0 runtime - researched solutions not working”
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found answer here via @pabrams. @pabrams additional comment under answer
"probably depends on what version of visual studio you're using, but for me (vs2010 pro) it was right-click project -> hit properties -> compile -> advanced compile options... -> generate serialization assemblies is a dropdown"did the trick!